NATURAL PORCINE SURFACTANT INHIBITS SUPEROXIDE ANIONS AND PROINFLAMMATORY MEDIATORS RELEASED BY STIMULATED HUMAN MONOCYTES. † 1491
نویسندگان
چکیده
منابع مشابه
Neurotoxic factors released by stimulated human monocytes and THP-1 cells.
Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditioned media against differentiated human NT-2 cells. Their cytotoxicity, as meas...
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Ghrelin, a recently described endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach cells and is a potent circulating orexigen, controlling energy expenditure, adiposity, and growth hormone secretion. However, the functional role of ghrelin in regulation of immune responses remains undefined. Here we report that GHS-R and ghrelin are expressed in human T...
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Monocytes are known to secrete upon LPS stimulation large amounts of a neutrophil-activating peptide originally termed MONAP (1), MDNCF (2), NAF (3), or GCP (4), and now called NAP-1/IL-8 (5) . With respect to the primary sequence, this novel cytokine (consisting of 72 amino acids in its major form) shows structural homology to 0-thromboglobulin-like host defense cytokines (2-4, 6) and is quite...
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Our previous study demonstrated that the smallest synthetic peptide with the sequence CPVHLKRLLLLLLLLLLLLLLLL, SP-CL16(6-28), admixed with phospholipid (synthetic lung surfactant, SLS) showed strong surface activity. In this study, we attempted to develop a dual-type surfactant with both anti inflammatory and surface activities. SP-CL16(6-28) was first chemically synthesized and then purified f...
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Chronic lung disease of prematurity/bronchopulmonary dysplasia (BPD) is the leading cause of perinatal morbidity in developed countries. Inflammation is a prominent finding. Currently available interventions have associated toxicities and limited efficacy. While BPD often resolves in childhood, survivors of preterm birth are at risk for acquired respiratory disease in early life and are more li...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-01514